Hyper-IgE Syndrome (Job’s Syndrome) is a genetic alteration that can lead to a chronic skin rash (eczema) and chronic infections, especially in the skin and lung.
IgE, or Immunoglobulin E, is an antibody that helps protect our body from certain infections. IgE is also made by the body during allergic reactions.
IgE can lead to allergic symptoms of:
Inheritance of Hyper-IgE Syndrome can be autosomal dominant, or recessive.
Patients with Hyper-IgE have trouble fighting harmful bacteria. The patient may develop the following symptoms:
As a child gets older, watch for:
Chest x-rays or chest CTs are done regularly to look for cysts in the lungs.
While there is no cure for Hyper-IgE syndrome, treatment focuses on stopping the symptoms. Some common treatments are: